Pemphigoid is one of the autoimmune bullous diseases. The disease is most common in people over 70 years of age. Blistering may be preceded by intense itching, and reddened patches and circular lesions are also seen on the skin. The blisters are large and not easily broken. They contain serous fluid. Blistering rarely spreads to the oral mucous membranes. The diagnosis is confirmed by immunofluorescence examination of a skin biopsy specimen.