Francisella tularensis is transmitted to humans by handling an infected animal, but also by mosquito bite, or even by ixodes. Incubation time is usually a few days. In the most common form, ulcero-glandular tularaemia, the inoculation site develops a red papule, which ulcerates. The regional lymph glands enlarge and the patient is febrile. The rising antibody titre is diagnostic.