"Periocular dermatitis" – a subgroup of perioral dermatitis, is rather common among women in early middle-age. Habitual use of creams and oils (also topical corticosteroids) is the only identified related factor. The best and invariably the most beneficial therapy is oral tetracycline at a dose of 500 mg o.d. for 2–3 months. This regimen gives a remission lasting on average for 3 years.